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Cinnamylamines make-up many important drugs that target G protein-coupled receptors. While 3,3-diarylallylamines can be prepared via existing synthetic methods, these often require poorly-selective Wittig addition to unsymmetrical ketones, and multistep sequences thereafter to reach the allylamine product. Methods that make use of direct aryl addition to N -protected cinnamylamines via a Mizoroki–Heck pathway are known, however, unprotected cinnamylamines are sensitive to a mixture of C–H activation and Mizoroki–Heck arylation under Pd-catalysed arylation conditions using aryl iodides. This leads to a decrease in the trans / cis selectivity that can be achieved under these reaction conditions. By reimagining the reaction and using aryl boronic acids, we have herein demonstrated how in many cases the yield and E / Z selectivity can be improved. The in situ -formed active catalyst is more sensitive under these conditions, and was observed to shut down at elevated temperatures. 

This Innovative Practice Full Paper presents a novel, narrative, game-based approach to introducing first-year engineering students to concepts in ethical decision making. Approximately 250 first-year engineering students at the University of Connecticut played through our adventure, titled Mars: An Ethical Expedition, by voting weekly as a class on a presented dilemma. Literature shows that case studies still dominate learning sciences research on engineering ethical education, and that novel, active learning-based techniques, such as games, are infrequently used but can have a positive impact on both student engagement and learning. In this work, we suggest that games are a form of situated (context-based) learning, where the game setting provides learners with an authentic but safe space in which to explore engineering ethical choices and their consequences. As games normalize learning through failure, they present a unique opportunity for students to explore ethical decision making in a non-judgmental, playful, and safe way.We explored the situated nature of ethical decision making through a qualitative deconstruction of the weekly scenarios that students engaged with over the course of the twelve-week narrative. To assess their ethical reasoning, students took the Engineering Ethics Reasoning Instrument (EERI), a quantitative engineering ethics reasoning survey, at the beginning and end of the semester. The EERI scenarios were deconstructed to reveal their core ethical dilemmas, and then common elements between the EERI and our Mars adventure were compared to determine how students responded to similar ethical dilemmas presented in each context.We noted that students' responses to the ethical decisions in the Mars adventure scenarios were sometimes substantially different both from their response to the EERI scenario as well as from other decisions they made within the context of the game, despite the core ethical dilemma being the same. This suggests that they make ethical decisions in some situations that differ from a presumed abstract understanding of post-conventional moral reasoning. This has implications for how ethical reasoning can be taught and scaffolded in educational settings. 

Abstract We present wide-field, high resolution maps of the color excess for 14 globular clusters toward the Southern Galactic bulge. The maps were derived using Gaia EDR3 astrometry and stellar photometry from the Blanco DECam Bulge Survey, which is a deep, wide-field ugriz Y photometric survey of the southern Galactic bulge. Comparisons with WISE 12 μ m images of thermal continuum emission demonstrate that the maps presented here trace interstellar extinction by dust down to 5″ scales. We use the reddening-corrected photometry of proper motion-selected cluster stars to build color–magnitude diagrams for the target globular clusters, which show residual broadening in excess of that expected from the photometric errors alone. This residual broadening is likely to be driven by star-to-star elemental abundance variations. 

Abstract We present photometric evidence for multiple stellar populations (MPs) in 14 globular clusters (GCs) toward the southern Galactic bulge. The photometric data come as part of the Blanco DECam Bulge Survey, which is a deep, wide-field near-UV-near-IR ( ugriz Y) survey of the southern Galactic bulge. Here, we present the first systematic study of bulge GC multiple populations with deep photometry including the u band, which is a crucial indicator of the abundance of CNO-bearing molecules in stellar atmospheres. We identify cluster members using Gaia EDR3 proper motion measurements, and then isolate red giant branch stars using r versus u − r color–magnitude diagrams. We find evidence suggesting all 14 clusters host at least two populations, and NGC 6441, NGC 6626, and NGC 6656 appear to have at least three populations. Many of these clusters are not part of the Hubble Space Telescope (HST) surveys nor do they have comprehensive spectroscopic analyses so we are presenting the first evidence of MPs in several clusters. Not only do we find a strong anticorrelation between the fraction of first-generation stars and cluster absolute V magnitude, but the correlation coefficient and cluster-to-cluster scatter are similar to the results obtained from HST. Our ground-based data extend to much larger radial distances than similar HST observations, enabling a reliable estimate of the global fraction of first-generation stars in each cluster. This study demonstrates that ground-based u -band photometry as provided by DECam will prove powerful in the study of multiple populations in resolved GCs. 

Aims. The Blanco DECam Bulge Survey (BDBS) has imaged more than 200 square degrees of the southern Galactic bulge, providing photometry in the ugrizy filters for ∼250 million unique stars. The presence of a strong foreground disk population, along with complex reddening and extreme image crowding, has made it difficult to constrain the presence of young and intermediate age stars in the bulge population. Methods. We employed an accurate cross-match of BDBS with the latest data release (EDR3) from the Gaia mission, matching more than 140 million sources with BDBS photometry and Gaia EDR3 photometry and astrometry. We relied on Gaia EDR3 astrometry, without any photometric selection, to produce clean BDBS bulge colour-magnitude diagrams (CMDs). Gaia parallaxes were used to filter out bright foreground sources, and a Gaussian mixture model fit to Galactic proper motions could identify stars kinematically consistent with bulge membership. We applied this method to 127 different bulge fields of 1 deg 2 each, with | ℓ | ≤ 9.5° and −9.5° ≤ b  ≤ −2.5°. Results. The astrometric cleaning procedure removes the majority of blue stars in each field, especially near the Galactic plane, where the ratio of blue to red stars is ≲10%, increasing to values ∼20% at higher Galactic latitudes. We rule out the presence of a widespread population of stars younger than 2 Gyr. The vast majority of blue stars brighter than the turnoff belong to the foreground population, according to their measured astrometry. We introduce the distance between the observed red giant branch bump and the red clump as a simple age proxy for the dominant population in the field, and we confirm the picture of a predominantly old bulge. Further work is needed to apply the method to estimate ages to fields at higher latitudes, and to model the complex morphology of the Galactic bulge. We also produce transverse kinematic maps, recovering expected patterns related to the presence of the bar and of the X-shaped nature of the bulge.